Concepedia

HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation

Lunzhi Yuan, Jing Jiang, Xuan Liu, Yali Zhang, Liang Zhang, Jiaojiao Xin, Kun Wu, Xiaoling Li, Jiali Cao, Xueran Guo,

Gut · 2019 · 57 citations · 25 references

DOIFull text

Open access

Abstract

This new humanised mouse model recapitulates the liver cirrhosis induced by human HBV infection, thus providing research opportunities for understanding viral immune pathophysiology and testing antiviral therapies in vivo.

References

25

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Humanized mice in translational biomedical research

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Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice

Hisaya Azuma, Nicole K. Paulk, Aarati R. Ranade et al. · Nature Biotechnology · 2007 · 811 citations · Full text

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The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization.

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