Concepedia

Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction

Assem Barakat, Mohammad Shahidul Islam, Hussien Mansur Ghawas, Abdullah Mohammed Al‐Majid, Fardous F. El‐Senduny, Farid A. Badria, Yaseen A. M. M. Elshaier, Hazem A. Ghabbour

Bioorganic Chemistry · 2019 · 76 citations · 51 references

DOI

Concepts

References

51

Cancer statistics, 2018

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2018 · 16.8K citations · Full text

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.6K citations

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Katsunori Nakano, Karen H. Vousden · Molecular Cell · 2001 · 2.3K citations · Full text

, , +5

The p53-mdm-2 autoregulatory feedback loop.

J. Henri Bayle, David C. Olson, Arnold J. Levine · Genes & Development · 1993 · 1.8K citations · Full text

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

Suzanne J. Baker, Sanford D. Markowitz, Eric R. Fearon et al. · Science · 1990 · 1.8K citations

, , +13