MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Lee P. Lim, Nelson C. Lau, Philip W. Garrett-Engele et al. · Nature · 2005 · 4.8K citations

Life Sciences, Molecular Biology, Molecular Genetics +16

Survival in Patients with Primary Pulmonary Hypertension

Gilbert E. D’Alonzo, Robyn J. Barst, Stephen M. Ayres et al. · Annals of Internal Medicine · 1991 · 3.5K citations

Medicine, Cardiology, Pulmonary Function Testing +12

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

Medicine, Cancer Biology, Molecular Biology +10

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Sébastien Bonnet, Stephen L. Archer, Joan Allalunis‐Turner et al. · Cancer Cell · 2007 · 1.5K citations · Full text

Life Sciences, Cancer Biology, Oncology +14

Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2

Yong Zhao, J. Ransom, Ankang Li et al. · Cell · 2007 · 1.4K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +16