Concepedia

Synergistic antitumour activity of HDAC inhibitor SAHA and EGFR inhibitor gefitinib in head and neck cancer: a key role for ΔNp63α

Simona Citro, Alice Bellini, Claudia Miccolo, Lavinia Ghiani, Thomas E. Carey, Susanna Chiocca

British Journal of Cancer · 2019 · 39 citations · 35 references

DOIFull text

Open access

Abstract

Our results, by giving a clear molecular mechanism at the basis of the antitumour activity of SAHA in HNC cell lines, provide a rationale for the clinical evaluation of SAHA in combination with gefitinib in both HPV-positive and HPV-negative HNC patients. Further knowledge is key to devising additional lines of combinatorial treatment strategies for this disease.

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35

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Open-Label, Uncontrolled, Multicenter Phase II Study to Evaluate the Efficacy and Toxicity of Cetuximab As a Single Agent in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Who Failed to Respond to Platinum-Based Therapy

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Keiko Akagi, Jingfeng Li, Tatevik Broutian et al. · Genome Research · 2013 · 468 citations · Full text