Concepedia

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

Ya‐Jen Chiu, Yu-Hsuan Hsieh, Te‐Hsien Lin, Guan-Chiun Lee, Hsiu Mei Hsieh‐Li, Ying‐Chieh Sun, Chiung‐Mei Chen, Kuo‐Hsuan Chang, Guey‐Jen Lee‐Chen

Neurochemistry International · 2019 · 22 citations · 51 references

DOI

Concepts

References

51

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

Fusheng Yang, Giselle P. Lim, Aynun N. Begum et al. · Journal of Biological Chemistry · 2004 · 2.3K citations · Full text

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The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Joseph T. Jarrett, Elizabeth P. Berger, Peter T. Lansbury · Biochemistry · 1993 · 2K citations

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[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

Harry LeVine · Methods in enzymology on CD-ROM/Methods in enzymology · 1999 · 1.4K citations

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Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

Suzanne E. Hickman, Elizabeth Allison, Joseph El Khoury · Journal of Neuroscience · 2008 · 1.3K citations · Full text

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