Enantioselective Aza-Heck Cyclizations of <i>N</i>-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines

Abstract

Pd(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates. The method provides versatile access to challenging N-heterocycles and represents the broadest scope enantioselective aza-Heck protocol developed to date.