World Journal of Gastroenterology · 2019 · 76 citations · 27 references
MedicineOncologyPathologyMetastasisMolecular OncologyTumor ProgressionCancer BiomarkersCirculating Tumor CellsEpithelial-mesenchymal TransitionEpithelial-to-mesenchymal TransitionPancreatic CancerTumor MarkersCirculating Tumor BiomarkersCirculating Tumor Cell BiomarkersCirculating Tumor Cell CharacterizationCirculating Tumor Cell EnumerationCirculating Tumor MarkersEpithelial-mesenchymal Transition MarkersNeutrophil-to-lymphocyte RatioPancreatic Cancer Detection
AIM: To evaluate the clinical properties of three subpopulations of circulating tumor cells (CTCs) undergoing epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) patients. METHODS: We identified CTCs for expression of the epithelial cell marker cytokeratin or epithelial cell adhesion molecule (EpCAM) (E-CTC), the mesenchymal cell markers vimentin and twist (M-CTC), or both (E/M-CTC) using the CanPatrol system. Between July 2014 and July 2016, 107 patients with PDAC were enrolled for CTC evaluation. CTC enumeration and classification were correlated with patient clinicopathological features and outcomes. RESULTS: < 0.01). CONCLUSION: Classifying CTCs by EMT markers helps to identify the more aggressive CTC subpopulations and provides useful evidence for determining a suitable clinical approach.
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Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2017 · 15K citations · Full text
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu, Aditya Bardia, Ben S. Wittner et al. · Science · 2013 · 2.5K citations
Medicine, Cell Biology, Oncology +12