The Journal of Organic Chemistry · 2019 · 43 citations · 109 references
Natural SciencesChemical EngineeringChemistryCatalysisElectrochemistryOrganic ChemistryCross-coupling ReactionsElectrochemical CellsElectrochemical SynthesisElectrode-electrolyte InterfacesIntermolecular InteractionsCurrent DensityElectrochemical C - O Bond FormationElectrochemical Coupling ReactionsElectrochemical Reaction MechanismsPlatinum ElectrodesSubstrate ScopeSubstrate Scope ScreeningUndivided Cells
The electrochemically induced cross-dehydrogenative C-O coupling of β-diketones and β-ketoesters (C-H reagents) with carboxylic acids (O-H reagents) was developed. An important feature of this reaction lies in the selective formation of intermolecular C-O coupling products in high yields, up to 92%, using DMSO as a solvent with a broad substrate scope in an undivided cell equipped with carbon and platinum electrodes at high current density. Electric current acts as a stoichiometric oxidant.
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