Concepedia

Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells

Xiaowen Guan, Vivian Rodriguez‐Cruz, Marilyn E. Morris

The AAPS Journal · 2019 · 105 citations · 34 references

DOI

Concepts

References

34

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Pierre Sonveaux, Frédérique Végran, Thies Schroeder et al. · Journal of Clinical Investigation · 2008 · 1.6K citations · Full text

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The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

Andrew P. Halestrap, Nigel T. Price · Biochemical Journal · 1999 · 1.3K citations · Full text

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The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

Mohammed S. Ullah, Andrew Davies, Andrew P. Halestrap · Journal of Biological Chemistry · 2006 · 868 citations · Full text

, , +17

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

Kai-Stefan DIMMER, Björn Friedrich, Florian Läng et al. · Biochemical Journal · 2000 · 554 citations · Full text

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Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

Radosław Polański, Cassandra L. Hodgkinson, Alberto Fusi et al. · Clinical Cancer Research · 2013 · 360 citations

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