Concepedia

Novel and Potent Dopamine D<sub>2</sub> Receptor Go-Protein Biased Agonists

Alessandro Bonifazi, Hideaki Yano, Adrian M. Guerrero, Vivek Kumar, Alexander F. Hoffman, Carl R. Lupica, Lei Shi, Amy Hauck Newman

ACS Pharmacology & Translational Science · 2019 · 58 citations · 52 references

DOIFull text

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Concepts

Abstract

Rs, which may be beneficial in the treatment of dyskinesias associated with dopamine system dysfunction.

References

52

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Ellen Y. T. Chien, Wei Liu, Qiang Zhao et al. · Science · 2010 · 1.1K citations

, , +17

Operational models of pharmacological agonism

J.W. Black, P. Leff · Proceedings of the Royal Society of London. Series B, Biological sciences · 1983 · 1.1K citations

, , +16

The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

Tanaji T. Talele · Journal of Medicinal Chemistry · 2016 · 989 citations · Full text

, , +7

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

Terry Kenakin, Christian Watson, Vanessa Muniz‐Medina et al. · ACS Chemical Neuroscience · 2011 · 486 citations

, , +17