Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology

TLDR

Cervical cancer is a malignant epithelial tumor of the uterine cervix, largely preventable by HPV vaccination, screening, and treatment of precancerous lesions, yet remains the fourth‑most common cancer in women worldwide due to inadequate screening. The manuscript aims to outline guiding principles for the workup, staging, and treatment of early‑stage and locally advanced cervical cancer. It presents evidence supporting these recommendations. Guidelines for recurrent or metastatic disease are available at NCCN.org.

Abstract

Cervical cancer is a malignant epithelial tumor that forms in the uterine cervix. Most cases of cervical cancer are preventable through human papilloma virus (HPV) vaccination, routine screening, and treatment of precancerous lesions. However, due to inadequate screening protocols in many regions of the world, cervical cancer remains the fourth-most common cancer in women globally. The complete NCCN Guidelines for Cervical Cancer provide recommendations for the diagnosis, evaluation, and treatment of cervical cancer. This manuscript discusses guiding principles for the workup, staging, and treatment of early stage and locally advanced cervical cancer, as well as evidence for these recommendations. For recommendations regarding treatment of recurrent or metastatic disease, please see the full guidelines on NCCN.org.