Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography

Abstract

This study demonstrates the ability of [¹⁸F]FSPG to detect upregulated antioxidant pathways present in drug-resistant cancer. [¹⁸F]FSPG may therefore enable the identification of patients with HGSOC that are refractory to standard of care, allowing the transferal of drug-resistant patients to alternative therapies, thereby improving outcomes in this disease.