Concepedia

Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

Lena Bosch, Judith de Haan, Tom Seijkens, Claudia M. van Tiel, Maike A. D. Brans, Gerard Pasterkamp, Esther Lutgens, Saskia C.A. de Jager

International Journal of Cardiology · 2018 · 18 citations · 10 references

DOIFull text

Open access

Concepts

References

10

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

Esther Lutgens, Dirk Lievens, Linda Beckers et al. · The Journal of Experimental Medicine · 2010 · 245 citations · Full text

, , +17

Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure

Tania Nevers, Ane Salvador, Francisco Velázquez et al. · The Journal of Experimental Medicine · 2017 · 226 citations

, , +17

T cell costimulation blockade blunts pressure overload-induced heart failure

Marinos Kallikourdis, Elisa Martini, Pierluigi Carullo et al. · Nature Communications · 2017 · 195 citations · Full text

, , +17

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Tom Seijkens, Claudia M. van Tiel, Pascal Kusters et al. · Journal of the American College of Cardiology · 2018 · 194 citations · Full text

, , +16

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

Antonios Chatzigeorgiou, Tom Seijkens, Barbara Zarzycka et al. · Proceedings of the National Academy of Sciences · 2014 · 125 citations · Full text

, , +17