Three new ɑ-pyrone derivatives induced by chemical epigenetic manipulation of <i>Penicillium herquei</i>, an endophytic fungus isolated from <i>Cordyceps sinensis</i>

Abstract

Chemical epigenetic manipulation was applied to explore secondary metabolite of an endophytic fungus <i>Penicillium herquei</i>, which was obtained from the fruiting body of <i>Cordyceps sinensis</i>, and three previously undescribed polyketides with pyran-2-one scaffold were isolated from its fermentation broth containing 10 mg/L 5-aza-2-deoxycytidine (a frequently-used DNA methyltransferase inhibitor). The structures of these new compounds were identified by extensive spectroscopic analyses, and their absolute configurations were elucidated by quantum chemical ECD calculations.