Concepedia

Publication | Open Access

Activation of RyR2 by class I kinase inhibitors

DOIFull Paper Access

16

Citations

39

References

2018

Year

Akash Deep Chakraborty, Luis Alberto Gonano, Michelle L. Munro, L J Smith, Chris Thekkedam, Verena Staudacher, Allan B. Gamble, Niall Macquaide, Angela F. Dulhunty, Peter P. Jones
British Journal of Pharmacology

Abstract

Part of the cardiotoxicity of class I kinase inhibitors can be assigned to their effect on RyR2 and increase in SOICR. Compounds with anti-SOICR activity may represent an improved treatment option for patients.

References

YearCitations

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