Ki-67 labeling index as a prognostic marker in advanced stomach cancer

Abstract

Ki-67, as a proliferation marker, is used to predict the prognosis of cancer Recently, various researches have focused on Ki-67 labeling index (LI) and its role in cancer Ki-67 LI is defined as the percentage of Ki-67 antigen positive cells. Nuclear protein Ki-67, known as a marker of cellular proliferation, seems to be correlated with cancer survival. The cell cycle is known to affect the status of Ki-67; Ki-67 is present in the G1, G2, S, and M phase, but not in the G0 phase A previous study by Lazr et al. [3] has shown that pathologic differentiation and p53