Concepedia

A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

Emmanuel Boulay, Matthew M. Abernathy, Ray W. Chui, Gregory S. Friedrichs, Nicolas Gendron-Parra, Andrea Greiter‐Wilke, Jean‐Michel Guillon, John Koerner, Ariane Menard, Jill Steidl‐Nichols,

International Journal of Toxicology · 2018 · 15 citations · 25 references

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Abstract

Results from this limited retrospective electrocardiogram analysis suggest that JTpca and Tpeca may discriminate selective I<sub>Kr</sub> blockers and multichannel blockers and could be considered in the context of an integrated comprehensive proarrhythmic risk assessment.

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