Comparison of Clinicopathological Features and Prognosis between <i>ALK</i> Rearrangements and <i>EGFR</i> Mutations in Surgically Resected Early-stage Lung Adenocarcinoma

Abstract

Clinicopathological features of LAC with <i>ALK</i> rearrangements differ from those of LAC with <i>EGFR</i> mutations. Patients with <i>ALK</i> rearrangements had a significantly worse DFS than those harboring <i>EGFR</i> mutations. Thus, <i>ALK</i> rearrangements are an adverse prognostic factor in surgically-resected LAC patients, while <i>EGFR</i> mutations are associated with a better prognosis.