Dorsal striatal dopamine D1 receptor availability predicts an instrumental bias in action learning

Abstract

Significance The brain’s dopaminergic pathways are crucially important for adaptive behavior. They are thought to enable us to approach rewards and stay away from punishments. During learning, dopaminergic reward prediction errors are thought to reinforce previously rewarded actions, so they become easier to repeat. This dopaminergic activity could lead to a systematic bias by which rewarded actions are more readily learned than rewarded inactions. We present two findings. First, dopamine receptors in cortex, dorsal striatum, and nucleus accumbens provide distinct sources of variance in the human brain. Second, the boost in an individual’s learning rate from previously rewarded actions is dependent on the dopamine receptor density in dorsal striatum, a central structure in the dopaminergic circuit.