Arrhythmogenic β-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

Luc M. Hondeghem, Dirk J. Snyders · Circulation · 1990 · 608 citations · Full text

Reduced Effectiveness, Translational Medicine, Heart Failure +15

Evidence of a Selective Increase in Cardiac Sympathetic Activity in Patients with Sustained Ventricular Arrhythmias

Ian T. Meredith, A. Broughton, Garry Jennings et al. · New England Journal of Medicine · 1991 · 416 citations

Adrenergic Effects on Ventricular Vulnerability

Jaok Han, P. García de Jalon, Gordon K. Moe · Circulation Research · 1964 · 381 citations · Full text

Hypertension, Heart Failure, Cardiac Anaesthesia +18

β-Adrenergic Enhancement of Sarcoplasmic Reticulum Calcium Leak in Cardiac Myocytes Is Mediated by Calcium/Calmodulin-Dependent Protein Kinase

Jerald W. Curran, M. Hinton, Donald M. Bers et al. · Circulation Research · 2007 · 296 citations

Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium.

Silvio Litovsky, Charles Antzelevitch · Circulation Research · 1990 · 265 citations · Full text

Cardiac Muscle, Heart Failure, Effective Refractory Period +17