Association of GALC, ZNF184, IL1R2 and ELOVL7 With Parkinson’s Disease in Southern Chinese

Abstract

<b>Study Objectives:</b> The aim of the study was to investigate the relationship between 22 single nucleotide polymorphisms (SNPs) and Parkinson's disease (PD) in the Chinese population. <b>Methods:</b> A total of 250 PD patients and 240 healthy controls were recruited. The SNaPshot technique and the polymer chain reaction were used to detect 22 SNPs. <b>Results:</b> rs8005172 of <i>GALC</i>, rs9468199 of <i>ZNF184</i> and rs34043159 of <i>IL1R2</i>, were associated with PD (rs8005172: <i>p</i> = 0.009, OR = 0.69, allele model, <i>p</i> = 0.010, additive model, <i>p</i> = 0.015, OR = 2.17, dominant model; <i>p</i> = 0.020, OR = 2.11, dominant model after adjustment; <i>p</i> = 0.036, OR = 1.47, recessive model after adjustment; rs9468199: <i>p</i> = 0.008, OR = 1.52, allele model, <i>p</i> = 0.008, additive model, <i>p</i> = 0.007, OR = 0.22, recessive model, <i>p</i> = 0.005, OR = 0.20, recessive model after adjustment; rs34043159: <i>p</i> = 0.034, OR = 1.31, allele model, <i>p</i> = 0.036, additive model). <b>Conclusion:</b> Our study revealed that <i>GALC</i>, <i>ZNF184</i>, and <i>IL1R2</i> were associated with PD in the southern Chinese population. <i>GALC</i> was also associated with LOPD. <i>ELOVL7</i> and <i>ZNF184</i> were associated with EOPD. In addition, trends of association to PD, between <i>SATB1</i>, <i>NMD3</i>, and <i>FGF20</i>, were also found. <b>Statement of Significance:</b> Genetic play an important role in the pathogenesis factors of Parkinson's disease (PD). We found that <i>GALC</i>, <i>ZNF184</i>, and <i>IL1R2</i> were associated with PD. <i>GALC</i> was also associated with late onset of PD, while <i>ELOVL7</i> and <i>ZNF184</i> were associated with early onset PD. This study is the first to find an association between <i>GALC</i>, <i>ZNF184</i>, and rs2280104 with PD.