Disruption of the ZBED6 binding site in intron 3 of IGF2 by CRISPR/Cas9 leads to enhanced muscle development in Liang Guang Small Spotted pigs

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.4K citations · Full text

Engineering, Genome Surgery, Genetics +7

A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig

Anne-Sophie Van Laere, Minh Quang Nguyen, Martin Braunschweig et al. · Nature · 2003 · 952 citations

Animal Physiology, Regulatory Mutation, Muscle Function +8

Surrogate reporters for enrichment of cells with nuclease-induced mutations

Hyojin Kim, Eunji Um, Sung‐Rae Cho et al. · Nature Methods · 2011 · 202 citations · Full text

Genome Instability, Surrogate Reporters, Dna Replication +4

Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs

Guanghai Xiang, Jilong Ren, Tang Hai et al. · Cellular and Molecular Life Sciences · 2018 · 105 citations · Full text

Animal Physiology, Nutrition, Xenotransplantation +15

The ZBED6–IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals

Shady Younis, Milena Schönke, Julie Massart et al. · Proceedings of the National Academy of Sciences · 2018 · 96 citations · Full text