Concepedia

MicroRNA-770 affects proliferation and cell cycle transition by directly targeting CDK8 in glioma

Junfeng Zhang, Jianshui Zhang, Zhaohua Zhao, Pengbo Yang, Shengfeng Ji, Nan Li, Qindong Shi, Jing Tan, Xi Xu, Cang‐Bao Xu,

Cancer Cell International · 2018 · 28 citations · 42 references

DOIFull text

Open access

Abstract

Our study demonstrates that miR-770 inhibits glioma cell proliferation and G1-S transition and induces apoptosis through suppression of the Wnt/β-catenin signaling pathway by targeting CDK8. These findings suggest that miR-770 plays a significant role in glioma progression and serves as a potential therapeutic target for glioma.

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