Concepedia

G1/s Transition

The G1/S Transition is a critical regulatory checkpoint in the eukaryotic cell cycle that marks the irreversible commitment of a cell to DNA replication and division, distinguishing it from other phase transitions by its dependence on the activation of cyclin-dependent kinases and integration of extracellular signals to ensure genomic stability.

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226K

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Authors

2.4K

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Publications per year

2017–2026

454

Parents

Publications

3K

The Pezcoller lecture: cancer cell cycles revisited.

C J Sherr · PubMed · 2000 · 1.2K citations

, , +17

Human Cyclin E, a Nuclear Protein Essential for the G<sub>1</sub>-to-S Phase Transition

Motoaki Ohtsubo, Anne M. Theodoras, Jill M. Schumacher et al. · Molecular and Cellular Biology · 1995 · 1.1K citations · Full text

, , +17

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

Ante S. Lundberg, Robert A. Weinberg · Molecular and Cellular Biology · 1998 · 1.1K citations

, , +17

D-type cyclin-dependent kinase activity in mammalian cells.

H Matsushime, Dawn E. Quelle, Sheila Shurtleff et al. · Molecular and Cellular Biology · 1994 · 1.1K citations · Full text

, , +12

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

Dawn E. Quelle, Richard A. Ashmun, Sheila Shurtleff et al. · Genes & Development · 1993 · 1K citations · Full text

, , +14

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Authors

14K

  1. SI
    Steven I. Reed

    Scripps Research Institute, United States

    27 publications · 6.1K citations

    26

    h-index

  2. AB
    Arthur B. Pardee

    Dana-Farber Cancer Institute, United States

    17 publications · 1.7K citations

    17

    h-index

  3. JL
    Janet L. Stein

    University of Massachusetts Chan Medical School, United States

    15 publications · 999 citations

    14

    h-index

  4. AJ
    André J. van Wijnen

    University of Massachusetts Chan Medical School, United States

    14 publications · 986 citations

    14

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  5. LA
    Lilia Alberghina

    University of Milano-Bicocca, Italy

    14 publications · 467 citations

    13

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1–5 of 14K

Institutions

2.4K

  1. Harvard University

    Cambridge, United States

    57 h-index

    286 publications

    33K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    43 h-index

    306 publications

    23.3K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    42 h-index

    133 publications

    33.9K citations

  4. Dana-Farber Cancer Institute

    Boston, United States

    38 h-index

    134 publications

    19.6K citations

  5. Inserm

    Paris, France

    35 h-index

    330 publications

    27.5K citations

  6. Scripps Research Institute

    San Diego, United States

    34 h-index

    119 publications

    24.6K citations

  7. The University of Tokyo

    Tokyo, Japan

    31 h-index

    181 publications

    14.1K citations

  8. University of California, San Francisco

    San Francisco, United States

    29 h-index

    94 publications

    12.2K citations

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Venues

  1. Molecular and Cellular Biology

    MCB · 231 publications · 31.2K citations

    100

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  2. Proceedings of the National Academy of Sciences

    PNAS · 129 publications · 16.5K citations

    74

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  3. Journal of Biological Chemistry

    JBC · 182 publications · 14.9K citations

    71

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  4. PubMed

    Repository · 178 publications · 12.4K citations

    59

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  5. Genes & Development

    50 publications · 12.9K citations

    47

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