Concepedia

Quantitative ubiquitylome analysis and crosstalk with proteome/acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma

Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li

Translational Cancer Research · 2018 · 21 citations · 44 references

Open access

Abstract

Our study extends our understanding of the spectrum of novel targets that are differentially ubiquitinated after perifosine treatment of NB tumor cells.

References

44

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

Woong Kim, Eric J. Bennett, Edward L. Huttlin et al. · Molecular Cell · 2011 · 1.6K citations · Full text

Proteomic Technology, Biochemistry, Protein Folding +6

A proteomics approach to understanding protein ubiquitination

Junmin Peng, Daniel Schwartz, Joshua E. Elias et al. · Nature Biotechnology · 2003 · 1.6K citations

Proteomic Technology, Protein Folding, Medicine +8

RAS Interaction with PI3K: More Than Just Another Effector Pathway

Esther Castellano, Julian Downward · Genes & Cancer · 2011 · 745 citations · Full text

Molecular Regulation, Hras-induced Skin Carcinogenesis, Complex Signaling Network +20

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

Asami Hagiwara, Marion Cornu, Nadine Cybulski et al. · Cell Metabolism · 2012 · 539 citations · Full text

Signal Transduction, Hepatology, Biochemistry +11

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Teru Hideshima, Laurence Catley, Hiroshi Yasui et al. · Blood · 2006 · 420 citations · Full text