Strain differences between CD-1 and C57BL/6 mice in expression of metabolic enzymes and DNA methylation modifications of the primary hepatocytes

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

Marianne Frommer, Louise E. McDonald, David Millar et al. · Proceedings of the National Academy of Sciences · 1992 · 3.3K citations

Life Sciences, Genetics, Molecular Biology +14

The Role of DNA Methylation in Mammalian Epigenetics

Peter A. Jones, Daiya Takai · Science · 2001 · 2.1K citations

Medicine, Genetics, Molecular Genetics +15

Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration

James Dunn, Martin L. Yarmush, H.G. Koebe et al. · The FASEB Journal · 1989 · 737 citations

Life Sciences, Bioengineering, Physiology +16

Long‐Term in Vitro Function of Adult Hepatocytes in a Collagen Sandwich Configuration

James Dunn, Ronald G. Tompkins, Martin L. Yarmush · Biotechnology Progress · 1991 · 703 citations

Life Sciences, Bioengineering, Cell Biology +15

An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

William F. Greenlee, Alan Poland · Journal of Pharmacology and Experimental Therapeutics · 1978 · 624 citations

Medicine, Biochemistry, Pharmacology +17