LncRNA MALAT1 Promotes Cancer Metastasis in Osteosarcoma via Activation of the PI3K-Akt Signaling Pathway - Concepedia

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LncRNA MALAT1 Promotes Cancer Metastasis in Osteosarcoma via Activation of the PI3K-Akt Signaling Pathway

DOI Full Paper Access

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2018

Year

Yong Chen, Wending Huang, Wei Sun, Biqiang Zheng, Chunmeng Wang, Zhiguo Luo, Jian Wang, Wangjun Yan

Cellular Physiology and Biochemistry

Abstract

Our data revealed for the first time that MALAT1 increases stem cell-like properties by up-regulating RET via sponging miR-129-5p, and thus activates the PI3K-Akt signaling pathway and provides potential therapeutic targets for osteosarcoma treatment.