The Antitumor and Immunomodulatory Effect of Yanghe Decoction in Breast Cancer Is Related to the Modulation of the JAK/STAT Signaling Pathway

Abstract

Our results showed that The mechanisms of YHD inhibit 4T1 breast tumor growth may be related to downregulating the expression of iNOS and ARG-1, negatively regulating the Janus kinase/STAT3 (JAK/STAT3) pathway by repressing the expression of IL-6 and TGF-<i>β</i>. Meanwhile, YHD enhances the immune capacity via increasing the expression of NKTs, CD4⁺ T cells, IFN-<i>γ</i>, and p-STAT1.