Open Forum Infectious Diseases · 2018 · 25 citations · 13 references
MedicineInfectious DiseasesPathologyHistopathologyMedical MicrobiologyVirologyHuman Papillomavirus InfectionOncogenic VirusesSexually Transmitted InfectionsViral DiagnosticsViral InfectionsCutaneous Human Papillomavirus InfectionGenital WartsHuman Papillomavirus - Related Skin LesionsHuman Papillomavirus-associated Histologic ChangesMisdiagnosis DetectionPathology MisdiagnosisVirological Diagnosis
Molluscum contagiosum (MC) manifests as small, umbilicated papules caused by the molluscum contagiosum virus (MCV). The extent of clinical misdiagnosis of MC is unknown. Combined clinical, histopathological, and virological evaluation of 203 consecutive patients with clinical diagnosis of MC treated at a university hospital during a 5-year period showed the correct clinical diagnosis in 188 of 203 (92.6%) patients. All 15 clinically misdiagnosed MC lesions were histopathologically and virologically confirmed as either common or anogenital warts caused by different human papillomaviruses. The MCV1/MCV2 subtypes ratio was 1.54:1, and the distribution of MCV subtypes differed across patients' age and anatomical location of lesions.
13