Mitochondrial targeting nanodrugs self-assembled from 9-O-octadecyl substituted berberine derivative for cancer treatment by inducing mitochondrial apoptosis pathways

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

Shigeomi Shimizu, Masashi Narita, Yoshihide Tsujimoto et al. · Nature · 1999 · 2.2K citations

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Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications

Jinjun Shi, Alexander R. Votruba, Omid C. Farokhzad et al. · Nano Letters · 2010 · 1.6K citations · Full text

Engineering, Bioengineering, Biomedical Engineering +13

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

Stanley J. Korsmeyer, John R. Shutter, Deborah J. Veis et al. · PubMed · 1993 · 874 citations

Life Sciences, Biochemistry, Cell Biology +12