AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

Abstract

Altogether ROS- and CaMKK-dependent AMPK activation is involved in P2X7-mediated mitophagy, mitochondrial dynamics and lysosomal biogenesis in microglial cells, which is followed by cytotoxicity partially resulting from mitophagy and cathepsin B activation.