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Downregulation of long noncoding RNA HOTAIRM1 variant 1 contributes to osteoarthritis via regulating miR-125b/BMPR2 axis and activating JNK/MAPK/ERK pathway

Yu Xiao, Yan Xu, Yang� Yang, Xinlong Ma

Biomedicine & Pharmacotherapy · 2018 · 86 citations · 27 references

DOIFull text

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Abstract

Our results indicate that HOTAIRM1-1 is downregulated in OA cartilages, and its downregulation may inhibit MSCs viability, induce apoptosis and suppress differentiation via regulating miR-125b/BMPR2 axis. JNK/MAPK/ERK pathway may be a possible downstream mechanism to mediate the role of HOTAIRM1-1 in OA development.

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