Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

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The sirtuin SIRT6 regulates lifespan in male mice

Yariv Kanfi, Shoshana Naiman, Gail Amir et al. · Nature · 2012 · 1K citations

Lifespan Extension, Developmental Biology, Longevity +6

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

Zhiyong Mao, Christopher Hine, Xiao Tian et al. · Science · 2011 · 850 citations · Full text

Overview and Findings from the Religious Orders Study

David A. Bennett, Julie A. Schneider, Zoe Arvanitakis et al. · Current Alzheimer Research · 2012 · 688 citations · Full text

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

Hong Jiang, Saba Khan, Yi Wang et al. · Nature · 2013 · 684 citations · Full text

Inflammation, Transcriptional Regulation, Protein Secretion +10