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Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro–In Silico–In Vivo Approach: Case Examples—Dipyridamole, Prasugrel, and Nelfinavir

Pharmacokinetic ModelingPharmacological StudyGastrointestinal PharmacologyPhysiologyPharmacologyGastroenterologyOral AbsorptionWeak Base DrugsClinical PharmacologyPharmacotherapyClinical ChemistryDrug AbsorptionElevated Gastric PhMedicinePhysiologically-based Pharmacokinetic ModelingPharmacodynamic ModelingDrug Analysis