Cell Metabolism · 2018 · 79 citations · 38 references
Life SciencesEndocrinologyPhysiologyBioenergeticsMetabolic RegulationMetabolismCarbohydrate MetabolismCellular RespirationDiabetes MellitusDiabetes Mellitus BiochemistryGlycemic ControlHyperosmolar Hyperglycemic StateAtp Production RateAtp Production ReductionGlucagon BiosynthesisGlucagon PhysiologyGlucagon Secretion RegulationGlucagon Signaling In Diabetes
channel mice, diabetic Goto-Kakizaki rats, and patients with type 2 diabetes. Succination is also observed in renal tubular cells and cardiomyocytes from hyperglycemic Fh1βKO mice, suggesting that the model can be extended to other SGLT-expressing cells and may explain part of the spectrum of diabetic complications.
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R: A Language and Environment for Statistical Computing
R Core Team · 2000 · 353K citations · Full text
Natural Sciences, Computer Science, Statistical Computing +10
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
Bernard Zinman, Christoph Wanner, John M. Lachin et al. · New England Journal of Medicine · 2015 · 12K citations · Full text
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
Christoph Wanner, Silvio E. Inzucchi, John M. Lachin et al. · New England Journal of Medicine · 2016 · 3.6K citations · Full text
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Yuval Dor, Juliana Brown, Olga I. Martinez et al. · Nature · 2004 · 2.2K citations