Journal of the American Chemical Society · 2018 · 78 citations · 35 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistryReaction EngineeringCarbonyl ChemistryCatalyst DesignCatalyst PreparationCatalyst SynthesisCross-coupling ReactionsOrganic SynthesisBenzoic Acid DerivativesCarbon Isotope EffectChemical Isotope ExchangeFunctional Group StructureIsotope Exchange ProcessesIsotope Exchange ReactionsNatural Product DerivativesPalladium Catalysts
An operationally simple protocol for a palladium-catalyzed 13CO and 14CO exchange with activated aliphatic and benzoic carbonyls is presented. Several 13C and 14C building blocks, natural product derivatives, and pharmaceuticals have been prepared to showcase the method for late-stage carbon isotope incorporation and its functional group compatibility.
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Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds
Yong Yao Loh, Kazunori Nagao, Andrew J. Hoover et al. · Science · 2017 · 571 citations
Philippe Hermange, Anders T. Lindhardt, Rolf H. Taaning et al. · Journal of the American Chemical Society · 2011 · 438 citations · Full text
Iron-catalysed tritiation of pharmaceuticals
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