A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma

Abstract

Persistent airway T2 inflammation is a complex construct of innate and adaptive immunity gene expression networks that are variable across individuals with asthma and persist despite steroid treatment. Individuals with T2-low asthma exhibit an airway deficiency in cytotoxic T cells associated with obesity-driven inflammation.