Protective effect of <i>Epicatechin</i> on APAP-induced acute liver injury of mice through anti-inflammation and apoptosis inhibition

Abstract

<i>Epicatechin</i> (EC) is the most effective compound in <i>Euonymus alatus (Thunb.)Sieb</i>, and possesses a series of benefits, including anti-inflammatory, antioxidant, antiobesity and anticancer effects. In this study, we investigated the protective effects of EC in Acetaminophen(N-acetyl-p-aminophenol, APAP)-induced acute liver injury in C57BL/6J mice and explored the possible mechanisms involved in these effects.[Formula: see text].