Concepedia

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

Daniel T. Cohen, Chi Zhang, Colin M. Fadzen, Alexander J. Mijalis, Liana Hie, Kenneth D. Johnson, Zachary Shriver, Obadiah J. Plante, Scott J. Miller, Stephen L. Buchwald,

Nature Chemistry · 2018 · 101 citations · 23 references

DOI

Concepts

References

23

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

Klaus‐Peter Lesch, Dietmar Bengel, Armin Heils et al. · Science · 1996 · 5.2K citations

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Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

Gail D. Lewis Phillips, Guangmin Li, Debra L. Dugger et al. · Cancer Research · 2008 · 1.7K citations

, , +17

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.4K citations

, , +16

Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia

Philip R. Hamann, Lois M. Hinman, Irwin Hollander et al. · Bioconjugate Chemistry · 2001 · 587 citations

, , +17

Tumor Imaging Using a Picomolar Affinity HER2 Binding Affibody Molecule

Anna Orlova, Mikaela Magnusson, Tove Eriksson et al. · Cancer Research · 2006 · 565 citations · Full text

, , +17