OncoTargets and Therapy · 2018 · 26 citations · 22 references
MedicineOncologyPathologyCancer ImmunologyMolecular OncologyTumor ImmunologyCancer BiomarkersColorectal CancerImmunohistochemistryTumor AntigensTumor MarkersTumor-associated AntigensClinicopathological CorrelationColorectal Cancer PathologyColorectal Cancer PrognosisPd-1 SignalingPd-l1 BlockadeProgrammed Cell Death Protein 1 (Pd-1) PathwayTherapeutic Target IdentificationTnm Staging System
BACKGROUND: (PD-L2), a ligand of programmed cell death protein 1 (PD-1), is an inhibitory receptor of T cells and activated B cells. Many studies have focused on PD-L1, another ligand of PD-1, and the prognostic significance of PD-L1 has been reported in many tumors. However, the expression of PD-L2 in relation to clinical outcomes has not been fully investigated in cancer patients. PATIENTS AND METHODS: In this study, we investigated the expression of PD-L2 via immunohistochemistry (IHC) in the pathological specimens of 348 patients treated for colorectal cancer (CRC). RESULTS: Strong PD-L2 expression was found in the cancer tissues from 41% of the CRC patients who also had a high TNM stage and carcinoembryonic antigen (CEA) concentration. We also carried out functional studies in vitro, which showed that PD-L2 did not influence the growth of the CRC cell line HCT116, but increased cell invasion. CONCLUSION: Collectively, these findings suggest that PD-L2 may be a potential therapeutic target for CRC.
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Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text
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Lindsey A. Torre, Freddie Bray, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians · 2015 · 27.4K citations · Full text
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
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