Short Chain Fatty Acids Upregulate Adipokine Production in Type 2 Diabetes Derived Human Adipocytes

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.3K citations

Obesity, Metabolic Syndrome, Knockout Mouse +10

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Toshimasa Yamauchi, Junji Kamon, Hironori Waki et al. · Nature Medicine · 2001 · 4.9K citations

Insulin Resistance, Metabolic Syndrome, Obesity +11

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

Yukio Arita, Shinji Kihara, Noriyuki Ouchi et al. · Biochemical and Biophysical Research Communications · 1999 · 4.8K citations

Obesity, Metabolic Syndrome, Metabolic Disorder +8

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

Andrew J. Brown, Susan M. Goldsworthy, Ashley Barnes et al. · Journal of Biological Chemistry · 2003 · 2.3K citations · Full text

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

Filipe De Vadder, Petia Kovatcheva‐Datchary, Daisy Goncalves et al. · Cell · 2014 · 2.1K citations · Full text

Dysbiosis, Gut-brain Neural Circuits, Medicine +10