Concepedia

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Ryanodine Receptor Glycation Favors Mitochondrial Damage in the Senescent Heart

DOI

78

Citations

29

References

2019

Year

Marisol Ruiz‐Meana, Marta Minguet, Diana Bou‐Teen, Elisabet Miró‐Casas, Celia Castans, José Castellano, Elena Bonzón‐Kulichenko, Alberto Igual, Rafael Rodríguez-Lecoq, Jesús Vázquez,
Circulation

Abstract

Mitochondria from aging hearts develop calcium overload secondary to SR calcium leak. Glycative damage of RyR2, favored by deficient dicarbonyl detoxification capacity, contributes to calcium leak and mitochondrial damage in the senescent myocardium.

References

YearCitations

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