Competitive Live-Cell Profiling Strategy for Discovering Inhibitors of the Quinolone Biosynthesis of <i>Pseudomonas aeruginosa</i>

Abstract

values. The effectiveness of our approach was ultimately demonstrated in P. aeruginosa by the complete shutdown of the production of quinolone quorum sensing signals and quinolone N-oxides and a considerable inhibition of the production of phenazine virulence factors.