P2‐292: MILD BEHAVIORAL IMPAIRMENT (MBI) IN MCI, SCD, AND NORMAL ELDERLY: A PILOT STUDY FOR VALIDATION OF THE MILD BEHAVIORAL IMPAIRMENT CHECKLIST (MBI‐C)

Abstract

Mild behavioral impairment (MBI) describes later life onset of sustained and impactful neuropsychiatric symptoms as a precursor to cognitive decline and dementia. The MBI checklist (MBI-C, Ismail et al., 2017) was newly developed based on the ISTAART-AA MBI criteria. The present study was conducted to examine that the MBI-C could be feasibly implemented in clinical settings as a pilot study for validation of the MBI-C in Korea. We administered the Korean version of MBI-C to 669 MCI patients [393 amnestic MCI (aMCI), 72 non-amnestic MCI (naMCI), 77 vascular MCI (vMCI), & 127 Parkinson's MCI (PD-MCI)], 173 subjective cognitive decline (SCD), and 68 normal elderly (NE) (Table 1). The MBI-C was completed by caregiver. The Caregiver Administered NPI (CGA-NPI) was also administered to a half of total participants (n=474). All participants were administered a comprehensive neuropsychological test battery for the clinical diagnosis. After controlling for demographics, we found that the total scores of MBI-C in aMCI, naMCI, and PD-MCI were significantly higher than that of normal elderly, but vMCI did not show any differences with SCD and NE (Table 2). There were no significant differences in “decreased motivation” domain scores among the MCI groups, while the PD-MCI and aMCI showed significantly higher scores than the SCD and NE. In the “emotional dysregulation” and “abnormal perception or thought content” domain scores, the PD-MCI showed the highest score, followed by naMCI. There were no significant differences among aMCI, vMCI, SCD, and NE. The aMCI and naMCI showed significantly higher “impulse dyscontrol” domain scores than the NE, while the vMCI and PD-MCI did not show differences with the SCD and NE. We did not find any group differences in “social inappropriateness” domain scores. Small but significant correlations between the MBI-C and CGA-NPI were found in aMCI (r=.25, p<.01) and naMCI (r=.36, p<.05). However, there were no correlations in vMCI, PD-MCI, and SCD. The results showed that the MBI-C could provide useful information on MBI of the MCI patients in clinical settings. Small or no correlations between the MBI and CGA-NPI indicated that the MBI had different characteristics with the CGA-NPI.