New Anthraquinone Derivative Produced by Cultivation of Mangrove Endophytic Fungus Fusarium sp. ZZF60 from the South China Sea

Abstract

A new anthraquinone derivative, 6, 8-dimethoxy-1-methyl-2-(3-oxobutyl) anthrakunthone (1), together with five known compounds, 7-hydroxy-3-(4-methoxyphenyl)-chromen-4-one(2), 2, 4-dihydroxy-6-[(1'E, 3'E)-penta-1', 3'-dienyl]-benzaldehyde(3), (E)-4hydroxycinnamic acid methyl ester(4), 4-(4-hydroxyphenyl)-butan2-ol(5), and 4-hydroxybenzoic acid(6), were isolated from the marine mangrove endophytic fungus Fusarium sp. ZZF60 from the South China Sea. Their structures were elucidated by spectral data of IR, MS and NMR. In the preliminary bioassay, compound 1 showed cytotoxicity towards Hep2 and HepG2 with IC50 values of 16μmol/L and 23μmol/L, respectively.