Dynamic coordination of two-metal-ions orchestrates λ-exonuclease catalysis

Exact stochastic simulation of coupled chemical reactions

Daniel T. Gillespie · The Journal of Physical Chemistry · 1977 · 10.4K citations

Engineering, Chemical Analysis, Altmetric Attention Score +19

Single-Molecule Enzymatic Dynamics

H. Peter Lu · 1998 · 1.5K citations

Single Molecule Biophysics, Single-molecule Enzymatic Dynamics, Biochemistry +11

Ligation-independent cloning of PCR products (LIC-PCR)

Charalampos Aslanidis, Pieter J. de Jong · Nucleic Acids Research · 1990 · 1.2K citations · Full text

A general two-metal-ion mechanism for catalytic RNA.

Thomas A. Steitz, J A Steitz · Proceedings of the National Academy of Sciences · 1993 · 1.1K citations

Chemical Catalysis, Catalytic Rna, Biochemistry +15

Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis

Marcin Nowotny, Sergei Gaidamakov, Robert J. Crouch et al. · Cell · 2005 · 602 citations · Full text

Rna/dna Hybrid, Engineering, Biochemistry +8