Transcriptomic and Protein Analysis of Small-cell Bladder Cancer (SCBC) Identifies Prognostic Biomarkers and DLL3 as a Relevant Therapeutic Target

Abstract

Gene expression patterns in SCBC are associated with distinct clinical phenotypes ranging from more indolent to aggressive disease. Overexpression of <i>DLL3</i> mRNA and protein is common in SCBC and correlates with shorter OS. A DLL3-targeted ADC demonstrated <i>in vivo</i> efficacy superior to chemotherapy in a PDX model of SCBC.