Journal of Biomedical Nanotechnology · 2018 · 49 citations · 0 references
PharmacyPharmaceuticsPharmacologyCancer PharmacologyChemotherapyDrug DeliveryCancer Drug DeliveryDrug EncapsulationLipid-based Drug Delivery SystemsNanocarriers For TherapeuticsNanoparticle DesignPolymeric Drug Delivery SystemsChemotherapy DeliveryControlled Drug ReleaseDrug Delivery NanocarriersDrug Release MechanismsDrug-loaded MicellesMicelle Drug DeliveryMicelle EncapsulationMicelles
. For U14 cervical carcinoma mouse model, all of the DOX-loaded micelles, especially SCM/DOX, effectively inhibited the progression of cervical carcinoma, as demonstrated by nearly stagnant tumor growth and increased apoptosis and necrosis areas within tumor tissue. Furthermore, these DOX-loaded micelles effectively alleviated the systemic toxicity of DOX. All the above results suggest that the DOX-loaded micelles, especially SCM/DOX, are an ideal drug delivery system for combating cervical carcinoma.