Flavopiridol's effects on metastasis in KRAS mutant lung adenocarcinoma cells

ras oncogenes in human cancer: a review.

Joyce Bos · PubMed · 1989 · 5.1K citations

Ras Gene Mutations, Tumor Biology, Ras Oncogenes +15

Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

Bradley A. Carlson, M M Dubay, Edward A. Sausville et al. · PubMed · 1996 · 537 citations

Breast Oncology, Chemoprevention Strategy, Cancer Biology +16

Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

Nathan T. Ihle, Lauren A. Byers, Edward S. Kim et al. · JNCI Journal of the National Cancer Institute · 2012 · 523 citations · Full text

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

Walter Filgueira de Azevedo, H J Mueller-Dieckmann, Ursula Schulze‐Gahmen et al. · Proceedings of the National Academy of Sciences · 1996 · 499 citations · Full text

Crystal Structure, Chemoprevention Strategy, Cell Cycle +23

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

Marta Puyol, Alberto Martín, Pierre Dubus et al. · Cancer Cell · 2010 · 408 citations · Full text

Oncogenic Agent, Medicine, Synthetic Lethal Interaction +11