Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors

Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

David C. Chan, Christine T. Chutkowski, Peter S. Kim · Proceedings of the National Academy of Sciences · 1998 · 475 citations

Life Sciences, Biochemistry, Molecular Biology +13

Discovery of 4-((3′<i>R</i>,4′<i>S</i>,5′<i>R</i>)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Angelo Aguilar, Jianfeng Lü, Liu Liu et al. · Journal of Medicinal Chemistry · 2017 · 203 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Atomic Interactions and Profile of Small Molecules Disrupting Protein–Protein Interfaces: the TIMBAL Database

Alícia P. Higueruelo, Adrian Schreyer, G. Richard Bickerton et al. · Chemical Biology & Drug Design · 2009 · 154 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

Development of Indole Compounds as Small Molecule Fusion Inhibitors Targeting HIV-1 Glycoprotein-41

Guangyan Zhou, Dong Wu, Beth A. Snyder et al. · Journal of Medicinal Chemistry · 2011 · 86 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Conserved Residue Lys574 in the Cavity of HIV-1 Gp41 Coiled-coil Domain Is Critical for Six-helix Bundle Stability and Virus Entry

Yuxian He, Shuwen Liu, Weiguo Jing et al. · Journal of Biological Chemistry · 2007 · 78 citations · Full text

Life Sciences, Biology, Molecular Biology +15